:root{--brand-50: #f2f5ff;--brand-100: #e4e9ff;--brand-200: #cbd6ff;--brand-300: #a9b8f5;--brand-400: #7d8be8;--brand-500: #5661c9;--brand-600: #454ba7;--brand-700: #363a82;--brand-800: #2a2d64;--ink-900: #1c2430;--ink-800: #2d3746;--slate-50: #f7f9f7;--slate-100: #eff4f1;--slate-200: #dde7e5;--slate-300: #c9d5dc;--slate-400: #a8b3be;--slate-500: #748192;--slate-600: #5b6878;--slate-700: #445163;--slate-800: #2d3746;--slate-900: #1c2430;--canvas: #f7f9f7;--surface: #ffffff;--science-teal: #1f7a68;--science-blue: #356db8;--science-sage: #6e8f64;--science-coral: #d96b6b;--science-lavender: #8e6dc8;--success-bg: #e6f7f2;--success-border: #bfe5dd;--warning: #9a6218;--warning-bg: #fff4d6;--warning-border: #edd48d;--error: #b42342;--error-bg: #fce7ed;--error-border: #f3b6c4;--info-bg: #eaf2ff;--info-border: #c9ddf2;--color-bg-app: var(--canvas);--color-bg-surface: var(--surface);--color-bg-subtle: var(--slate-50);--color-bg-muted: var(--slate-100);--color-bg-header: var(--ink-900);--color-bg-header-secondary: var(--ink-800);--color-border: var(--slate-300);--color-border-subtle: var(--slate-200);--color-border-strong: var(--slate-400);--color-text: var(--ink-900);--color-text-secondary: var(--slate-700);--color-text-helper: var(--slate-600);--color-text-muted: var(--slate-500);--color-text-disabled: var(--slate-400);--color-text-inverse: var(--surface);--color-action-primary: var(--brand-500);--color-action-accent: var(--brand-400);--color-action-primary-hover: var(--brand-600);--color-action-primary-active: var(--brand-700);--color-action-subtle-hover-bg: var(--brand-100);--color-action-selected-bg: var(--brand-50);--color-action-selected-border: var(--brand-200);--color-action-selected-border-strong: var(--brand-300);--color-action-selected-text: var(--brand-600);--color-action-selected-text-strong: var(--brand-800);--color-focus-ring: var(--brand-100);--color-success: var(--science-teal);--color-success-bg: var(--success-bg);--color-success-border: var(--success-border);--color-success-text: var(--science-teal);--color-info: var(--science-blue);--color-info-bg: var(--info-bg);--color-info-border: var(--info-border);--color-info-text: var(--science-blue);--color-warning: var(--warning);--color-warning-bg: var(--warning-bg);--color-warning-border: var(--warning-border);--color-warning-text: var(--warning);--color-error: var(--error);--color-error-bg: var(--error-bg);--color-error-border: var(--error-border);--color-error-text: var(--error);--color-chart-text: var(--color-text);--color-chart-grid: var(--color-border-subtle);--color-chart-grid-strong: var(--color-border);--color-chart-zero-line: var(--color-border-strong);--color-chart-plot-surface: var(--color-bg-subtle);--color-chart-paper-surface: var(--color-bg-surface);--color-chart-legend-surface: var(--color-bg-surface-translucent);--color-overlay-on-dark: rgb(255 255 255 / 6%);--color-overlay-on-dark-strong: rgb(255 255 255 / 14%);--color-overlay-on-dark-border: rgb(255 255 255 / 14%);--color-bg-surface-translucent: rgb(255 255 255 / 88%);--shadow-control-highlight: inset 0 1px 0 rgb(255 255 255 / 75%);--shadow-control-raised: 0 1px 2px rgb(0 0 0 / 15%);--shadow-sm: 0 1px 2px rgb(0 0 0 / 5%);--shadow-md: 0 4px 6px -1px rgb(0 0 0 / 10%);--shadow-lg: 0 10px 15px -3px rgb(0 0 0 / 10%);--primary-50: var(--brand-50);--primary-100: var(--brand-100);--primary-200: var(--brand-200);--primary-300: var(--brand-300);--primary-400: var(--brand-400);--primary-500: var(--brand-500);--primary-600: var(--brand-600);--primary-700: var(--brand-700);--primary-800: var(--brand-800);--blue-50: var(--color-info-bg);--blue-200: var(--color-info-border);--blue-600: var(--color-info);--green-50: var(--color-success-bg);--green-100: var(--color-success-bg);--green-200: var(--color-success-border);--green-600: var(--color-success);--amber-50: var(--color-warning-bg);--amber-100: var(--color-warning-bg);--amber-200: var(--color-warning-border);--amber-700: var(--color-warning);--amber-800: var(--color-warning-text);--red-50: var(--color-error-bg);--red-100: var(--color-error-bg);--red-200: var(--color-error-border);--red-600: var(--color-error);--red-700: var(--color-error-text);--success: var(--color-success);--success-text: var(--color-success-text);--warning-text: var(--color-warning-text);--error-text: var(--color-error-text)}:root{--space-1: 4px;--space-2: 8px;--space-3: 12px;--space-4: 16px;--space-5: 20px;--space-6: 24px;--space-8: 32px;--radius-sm: 4px;--radius-md: 6px;--radius-lg: 8px;--radius-xl: 12px}.app{display:flex;flex-direction:column;min-height:100vh;background:var(--color-bg-app)}.app-header{background:var(--color-bg-header);color:var(--color-text-inverse);padding:var(--space-4) var(--space-6);box-shadow:var(--shadow-md);position:sticky;top:0;z-index:100}.header-content{max-width:1400px;margin:0 auto;display:flex;justify-content:space-between;align-items:center;gap:var(--space-5)}.header-brand{display:flex;align-items:center;gap:var(--space-3);min-width:260px}.brand-mark{display:inline-flex;align-items:center;justify-content:center;flex:0 0 auto;width:54px;height:54px;padding:6px;border:1px solid var(--color-overlay-on-dark-border);border-radius:var(--radius-lg);background:var(--color-bg-surface);box-shadow:var(--shadow-control-raised);overflow:hidden}.brand-mark img{display:block;width:100%;height:100%;object-fit:contain;transform:scale(1.42)}.header-title{min-width:0}.header-title h1{font-size:23px;font-weight:700;margin-bottom:2px;letter-spacing:0}.header-title .subtitle{font-size:14px;opacity:.85;font-weight:400}.brand-affiliation{display:flex;flex-wrap:wrap;gap:6px;align-items:center;margin-top:var(--space-2);color:var(--color-text-inverse);font-size:11px;font-weight:800;letter-spacing:.06em;line-height:1.2;text-transform:uppercase}.brand-affiliation span{display:inline-flex;align-items:center;min-height:22px;padding:0 var(--space-2);border:1px solid var(--color-overlay-on-dark-border);border-radius:var(--radius-sm);background:var(--color-overlay-on-dark)}.header-nav{display:flex;gap:var(--space-2);min-width:0;flex:1 1 auto;overflow-x:auto;overscroll-behavior-x:contain;scrollbar-width:thin}.nav-tab{background:var(--color-overlay-on-dark);border:1px solid var(--color-overlay-on-dark-border);color:var(--color-text-inverse);padding:var(--space-2) var(--space-4);border-radius:var(--radius-md);font-size:14px;font-weight:500;cursor:pointer;transition:all .2s ease}.nav-tab:hover{background:var(--color-overlay-on-dark-strong)}.nav-tab.active{background:var(--color-action-primary);color:var(--color-text-inverse);border-color:var(--color-action-primary)}.header-session{display:flex;flex:0 0 auto;align-items:center;gap:var(--space-2);max-width:190px}.header-session-name{overflow:hidden;color:var(--color-text-inverse);font-size:12px;font-weight:600;text-overflow:ellipsis;white-space:nowrap}.header-sign-out{flex:0 0 auto;padding:var(--space-2) var(--space-3);border:1px solid var(--color-overlay-on-dark-border);border-radius:var(--radius-md);background:var(--color-overlay-on-dark);color:var(--color-text-inverse);font:inherit;font-size:12px;font-weight:600;cursor:pointer}.header-sign-out:hover{background:var(--color-overlay-on-dark-strong)}.app-main{flex:1;min-width:0;padding:var(--space-6)}.main-content{min-width:0;width:100%;max-width:1400px;margin:0 auto}.app-footer{background:var(--color-bg-header-secondary);color:var(--color-text-disabled);text-align:center;padding:var(--space-4);font-size:13px;line-height:1.6}.app-footer p{max-width:960px;margin:0 auto}.app-footer strong{color:var(--color-text-inverse);font-weight:800}.app-footer a{color:var(--color-text-inverse);font-weight:700;text-decoration-color:var(--color-overlay-on-dark-border);text-underline-offset:3px}.app-footer a:hover{color:var(--color-action-subtle-hover-bg)}.trial-description-banner{margin:var(--space-4) 0 0;border:1px solid var(--color-action-selected-border);border-radius:var(--radius-md);background:var(--color-action-selected-bg);overflow:hidden}.trial-description-toggle{display:flex;align-items:center;gap:var(--space-2);width:100%;padding:var(--space-2) var(--space-4);background:transparent;border:none;cursor:pointer;text-align:left;color:var(--color-action-primary-active);font-size:13px;font-weight:500}.trial-description-toggle:hover{background:var(--color-action-subtle-hover-bg)}.trial-description-icon{font-style:normal;font-size:14px}.trial-description-title{flex:1}.trial-description-chevron{font-size:10px;color:var(--color-text-disabled)}.trial-description-text{margin:0;padding:0 var(--space-4) var(--space-3);font-size:13px;line-height:1.6;color:var(--color-text-secondary)}.bland-altman-page,.audpc-page{background:var(--color-bg-surface);border-radius:var(--radius-xl);box-shadow:var(--shadow-md);padding:var(--space-6)}.compare-audpc-page .compare-controls,.compare-bland-altman-page .compare-controls{align-items:stretch}.analysis-workspace{display:flex;flex-direction:column;gap:var(--space-4);max-width:1440px;margin:0 auto}.analysis-workspace-scope,.analysis-workspace-header,.analysis-workspace-strip,.analysis-workspace-timeline,.analysis-workspace-advanced,.analysis-workspace-primary{min-width:0}.dataset-scope-bar{display:flex;flex-direction:column;gap:0;padding:0;border:1px solid var(--color-border-subtle);border-radius:var(--radius-lg);background:var(--color-bg-surface);box-shadow:var(--shadow-sm);overflow:hidden}.dataset-scope-band{padding:var(--space-4)}.dataset-scope-band--context{background:linear-gradient(180deg,var(--color-bg-subtle) 0%,var(--color-bg-app) 100%);border-bottom:1px solid var(--color-border-subtle)}.dataset-scope-band--analysis{position:relative;background:var(--color-bg-surface)}.dataset-scope-band--analysis:before{content:"";position:absolute;top:var(--space-4);bottom:var(--space-4);left:0;width:4px;border-radius:0 var(--radius-sm) var(--radius-sm) 0;background:var(--color-action-primary)}.dataset-scope-band-header{display:flex;align-items:center;margin-bottom:var(--space-3)}.dataset-scope-band-label{display:inline-flex;align-items:center;min-height:22px;padding:0 var(--space-2);border:1px solid var(--color-border-subtle);border-radius:var(--radius-sm);background:var(--color-bg-surface);color:var(--color-text-helper);font-size:11px;font-weight:800;letter-spacing:.06em;text-transform:uppercase}.dataset-scope-band--analysis .dataset-scope-band-label{border-color:var(--color-action-selected-border);background:var(--color-action-selected-bg);color:var(--color-action-selected-text)}.dataset-scope-filters,.dataset-scope-primary{display:grid;grid-template-columns:repeat(auto-fit,minmax(160px,1fr));gap:var(--space-3);align-items:end}.dataset-scope-primary{grid-template-columns:minmax(240px,1.8fr) repeat(auto-fit,minmax(140px,1fr))}.dataset-scope-bar label{display:flex;flex-direction:column;gap:6px;color:var(--color-text-helper);font-size:12px;font-weight:800;letter-spacing:.01em}.dataset-scope-bar select{-webkit-appearance:none;-moz-appearance:none;appearance:none;width:100%;min-height:42px;padding:0 42px 0 var(--space-3);border:1px solid var(--color-border);border-radius:var(--radius-md);background-color:var(--color-bg-surface);background-image:linear-gradient(45deg,transparent 50%,var(--color-text-muted) 50%),linear-gradient(135deg,var(--color-text-muted) 50%,transparent 50%);background-position:calc(100% - 18px) 50%,calc(100% - 12px) 50%;background-repeat:no-repeat;background-size:6px 6px;color:var(--color-text);font-size:14px;font-weight:600;line-height:1.2;box-shadow:var(--shadow-control-highlight);cursor:pointer;transition:border-color .15s ease,box-shadow .15s ease,background-color .15s ease}.dataset-scope-bar select:hover{border-color:var(--color-border-strong);background-color:var(--color-bg-subtle)}.dataset-scope-bar select:focus{outline:none;border-color:var(--color-action-primary);box-shadow:0 0 0 3px var(--color-focus-ring)}.dataset-scope-bar select:disabled{cursor:not-allowed;background-color:var(--color-bg-muted);color:var(--color-text-muted);opacity:1}.dataset-scope-band--context select{min-height:38px;background-color:var(--color-bg-surface-translucent);font-size:13px}.dataset-scope-clear{min-height:38px;border:1px solid var(--color-border);border-radius:var(--radius-md);background:var(--color-bg-surface);color:var(--color-text-secondary);font-weight:700;cursor:pointer;transition:border-color .15s ease,color .15s ease,background .15s ease}.dataset-scope-clear:hover:not(:disabled){border-color:var(--color-action-selected-border);background:var(--color-action-selected-bg);color:var(--color-action-selected-text)}.dataset-scope-clear:disabled{cursor:not-allowed;opacity:.55}.dataset-scope-message{margin:0;padding:0 var(--space-4) var(--space-3);color:var(--color-warning);font-size:13px}.multi-year-page{display:flex;flex-direction:column;gap:var(--space-4)}.multi-year-context-fields{grid-template-columns:minmax(260px,1.5fr) minmax(180px,.8fr) minmax(280px,2fr) auto}.multi-year-analysis-fields{grid-template-columns:repeat(auto-fit,minmax(180px,1fr))}.multi-year-setup-status{display:grid;gap:var(--space-2);margin-top:var(--space-3);padding:var(--space-3);border:1px solid var(--color-border-subtle);border-radius:var(--radius-md);background:var(--color-bg-subtle);color:var(--color-text-secondary);font-size:12px;line-height:1.4}.multi-year-setup-status>div{display:flex;flex-wrap:wrap;gap:var(--space-2);align-items:baseline}.multi-year-setup-status strong{color:var(--color-text);font-weight:800}.multi-year-setup-label{min-width:110px;color:var(--color-text-helper);font-weight:800;text-transform:uppercase}.multi-year-year-group{display:flex;flex-direction:column;gap:6px;min-width:0}.multi-year-year-header{display:flex;align-items:center;justify-content:space-between;gap:var(--space-2);color:var(--color-text-helper);font-size:12px;font-weight:800;letter-spacing:.01em}.multi-year-year-header span:last-child{color:var(--color-text-muted);font-size:11px;font-weight:700}.multi-year-year-options{display:flex;flex-wrap:wrap;gap:var(--space-2);align-items:center;min-height:38px}.dataset-scope-bar .multi-year-year-chip{display:inline-flex;flex-direction:row;align-items:center;gap:6px;min-height:32px;padding:0 var(--space-3);border:1px solid var(--color-border);border-radius:var(--radius-md);background:var(--color-bg-surface-translucent);color:var(--color-text-secondary);cursor:pointer;font-size:13px;font-weight:700;letter-spacing:0;-webkit-user-select:none;user-select:none;transition:border-color .15s ease,background .15s ease,color .15s ease}.dataset-scope-bar .multi-year-year-chip:hover{border-color:var(--color-action-selected-border);background:var(--color-action-selected-bg);color:var(--color-action-primary-active)}.dataset-scope-bar .multi-year-year-chip.selected{border-color:var(--color-action-selected-border-strong);background:var(--color-action-selected-bg);color:var(--color-action-primary-active)}.multi-year-year-chip input{margin:0;accent-color:var(--color-action-selected-text)}.multi-year-reset{align-self:end;padding:0 var(--space-4)}.multi-year-control-error{margin-bottom:var(--space-3)}.multi-year-materials-section{min-width:0;flex:none;background:var(--color-bg-surface)}.multi-year-material-year{margin-bottom:var(--space-3)}.multi-year-material-year:last-child{margin-bottom:0}.dataset-summary-header{display:flex;flex-direction:column;gap:var(--space-3);padding:var(--space-5);border:1px solid var(--color-border-subtle);border-radius:var(--radius-lg);background:var(--color-bg-surface);box-shadow:var(--shadow-sm)}.dataset-summary-main{display:flex;justify-content:space-between;gap:var(--space-4);align-items:flex-start}.dataset-summary-kicker{margin:0 0 var(--space-1);color:var(--color-success);font-size:12px;font-weight:800;text-transform:uppercase}.dataset-summary-header h2{margin:0;color:var(--color-text);font-size:24px;font-weight:800}.dataset-summary-badges,.dataset-summary-context,.dataset-summary-tags{display:flex;flex-wrap:wrap;gap:var(--space-2)}.dataset-summary-badges span,.dataset-summary-context span,.dataset-summary-tags span{display:inline-flex;align-items:center;min-height:28px;padding:0 var(--space-3);border:1px solid var(--color-border-subtle);border-radius:var(--radius-md);background:var(--color-bg-subtle);color:var(--color-text-secondary);font-size:13px;font-weight:700}.dataset-summary-context span{background:var(--color-success-bg);border-color:var(--color-success-border);color:var(--color-success-text)}.dataset-summary-description{max-width:960px;margin:0;color:var(--color-text-helper);font-size:14px;line-height:1.55}.feature-strip{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:var(--space-2);padding:var(--space-2);border:1px solid var(--color-border-subtle);border-radius:var(--radius-lg);background:var(--color-bg-surface);box-shadow:var(--shadow-sm)}.feature-strip-item{display:flex;flex-direction:column;align-items:flex-start;gap:2px;min-height:56px;padding:var(--space-3);border:1px solid transparent;border-radius:var(--radius-md);background:transparent;color:var(--color-text-helper);cursor:pointer;text-align:left}.feature-strip-item:hover{background:var(--color-bg-subtle)}.feature-strip-item.active{border-color:var(--color-action-selected-border);background:var(--color-action-selected-bg);color:var(--color-action-selected-text-strong)}.feature-strip-item:disabled{cursor:not-allowed;opacity:.45}.feature-strip-label{font-size:14px;font-weight:800;overflow-wrap:anywhere}.feature-strip-detail{font-size:12px;color:var(--color-text-muted)}.timepoint-timeline{display:flex;gap:var(--space-2);overflow-x:auto;padding:var(--space-2);border:1px solid var(--color-border-subtle);border-radius:var(--radius-lg);background:var(--color-bg-surface);box-shadow:var(--shadow-sm)}.timepoint-timeline-item{display:flex;flex-direction:column;justify-content:center;gap:2px;min-width:112px;min-height:54px;padding:var(--space-2) var(--space-3);border:1px solid var(--color-border-subtle);border-radius:var(--radius-md);background:var(--color-bg-subtle);color:var(--color-text-secondary);cursor:pointer;text-align:left}.timepoint-timeline-item.active{border-color:var(--color-action-selected-border);background:var(--color-action-selected-bg);color:var(--color-action-selected-text)}.timepoint-timeline-item:disabled{cursor:not-allowed;opacity:.48}.timepoint-timeline-item:disabled:not(.active){background:var(--color-bg-muted);color:var(--color-text-muted)}.timepoint-timeline-index{font-size:12px;font-weight:800}.timepoint-timeline-label{font-size:12px;white-space:nowrap}.visible-analysis-controls{display:flex;flex-direction:column;gap:var(--space-3);padding:var(--space-4);border:1px solid var(--color-border-subtle);border-radius:var(--radius-lg);background:var(--color-bg-surface);box-shadow:var(--shadow-sm)}.visible-analysis-controls-header{display:flex;justify-content:space-between;gap:var(--space-4);align-items:center}.visible-analysis-controls-header>div{min-width:0}.visible-analysis-controls-header h2{margin:0;color:var(--color-text);font-size:15px;font-weight:800}.visible-analysis-controls-header p{margin:2px 0 0;color:var(--color-text-muted);font-size:12px}.reset-filters-button.visible-analysis-reset{width:auto;min-width:150px;flex:0 0 auto;align-self:center;white-space:nowrap}.advanced-controls-layout{display:grid;grid-template-columns:minmax(220px,.72fr) minmax(280px,1fr) minmax(300px,1fr);gap:var(--space-3);align-items:start}.advanced-controls-layout-primary{grid-template-columns:minmax(280px,.72fr) minmax(420px,1fr)}.advanced-controls-layout .control-section,.advanced-controls-layout .treatment-filter-section,.advanced-controls-layout .graph-display-section{min-width:0;box-shadow:none}.advanced-controls-layout .control-section{gap:var(--space-3);padding:var(--space-3);background:var(--color-bg-surface)}.advanced-controls-layout .treatment-filter-header,.advanced-controls-layout .graph-display-header{padding:10px var(--space-3)}.advanced-controls-layout .treatment-filter-content,.advanced-controls-layout .graph-display-content{gap:var(--space-3);padding:var(--space-3)}.advanced-controls-layout .control-group{min-width:0}.advanced-controls-layout .control-group label,.advanced-controls-layout .control-section-title,.advanced-controls-layout .treatment-filter-title,.advanced-controls-layout .graph-display-title{font-size:11px;letter-spacing:.06em}.advanced-controls-layout .control-group select,.advanced-controls-layout .control-group input[type=number],.advanced-controls-layout .multiselect-button{min-height:38px;font-size:13px}.advanced-controls-layout .sort-controls{display:grid;grid-template-columns:repeat(auto-fit,minmax(120px,1fr));gap:var(--space-3)}.advanced-checkbox-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:var(--space-2)}.advanced-checkbox-grid .toggle-label{display:flex;align-items:center;gap:var(--space-2);min-height:34px;padding:6px var(--space-2);border:1px solid var(--color-border-subtle);border-radius:var(--radius-md);background:var(--color-bg-subtle);color:var(--color-text-secondary);font-size:12px;font-weight:700;text-transform:none;letter-spacing:0}.advanced-checkbox-grid input[type=checkbox]{margin:0;accent-color:var(--color-action-selected-text)}.workspace-controls{margin-bottom:0;padding-bottom:0;border-bottom:0}.single-source-metric-page .plot-section,.single-source-metric-page .source-metric-plot{margin-top:0}.toggle-group{display:flex;gap:var(--space-2);padding:4px;border-radius:var(--radius-md);background:var(--color-bg-muted);border:1px solid var(--color-border-subtle)}.toggle-button{flex:1;border:1px solid transparent;background:transparent;color:var(--color-text-helper);padding:6px 10px;border-radius:var(--radius-sm);font-size:13px;font-weight:600;cursor:pointer;transition:background .2s ease,color .2s ease,border-color .2s ease}.toggle-button.active{background:var(--color-bg-surface);color:var(--color-action-primary-active);border-color:var(--color-border-subtle);box-shadow:var(--shadow-sm)}.toggle-button:hover{color:var(--color-action-primary-active)}.control-section{display:flex;flex-direction:column;gap:var(--space-4);padding:var(--space-4);border:1px solid 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768px){.ppb-clouds-page{padding:var(--space-4)}.ppb-clouds-header{flex-direction:column;gap:var(--space-3)}.ppb-clouds-layout{grid-template-columns:1fr}.ppb-clouds-rail{position:static}.ppb-clouds-chart-card{padding:var(--space-2)}}@media (max-width: 480px){.ppb-clouds-page{padding:var(--space-3)}.ppb-clouds-header h2{font-size:22px}.ppb-clouds-rail{padding:var(--space-3)}}.dataset-source-builder,.dataset-source-manager{display:grid;gap:var(--space-4);margin-top:var(--space-4);padding:var(--space-4);border:1px solid var(--color-border-subtle);border-radius:var(--radius-lg);background:var(--color-bg-subtle)}.dataset-source-manager{margin-top:var(--space-5);background:var(--color-bg-surface);box-shadow:var(--shadow-sm)}.dataset-source-section-header{display:flex;align-items:flex-start;justify-content:space-between;gap:var(--space-4)}.dataset-source-section-header 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